PHARMACOKINETIC DRUG INTERACTION WITH GRAPEFRUIT JUICE
نویسندگان
چکیده
منابع مشابه
Oral midazolam-grapefruit juice drug interaction.
Oral midazolam is a frequently used sedative in pediatric dentistry. Although an oral form of midazolam is now commercially available, some practitioners continue to use the IV midazolam as an oral medication. If the injectible form of midazolam is administered orally, its bitter taste requires the use of a flavoring agent. Grapefruit juice is contraindicated for this purpose as it inhibits cyt...
متن کاملGrapefruit juice-drug interactions.
The novel finding that grapefruit juice can markedly augment oral drug bioavailability was based on an unexpected observation from an interaction study between the dihydropyridine calcium channel antagonist, felodipine, and ethanol in which grapefruit juice was used to mask the taste of the ethanol. Subsequent investigations showed that grapefruit juice acted by reducing presystemic felodipine ...
متن کاملRelationship between lipophilicities of 1,4-dihydropyridine derivatives and pharmacokinetic interaction strengths with grapefruit juice.
It is well known fact that the strengths of drug interactions with grapefruit juice (GFJ) differ greatly depending on the 1,4-dihydropyridine calcium channel antagonist (DHP) used. However, there are no available data on the relationship between interactions with GFJ and its physicochemical attributes. Therefore we endeavored to study the correlation between calculated logP values, indicating l...
متن کاملAmounts and variation in grapefruit juice of the main components causing grapefruit-drug interaction.
A method for the determination of three furocoumarins containing two new chemicals (GF-I-1 and GF-I-4) in commercially available grapefruit juice and grapefruit itself was developed using high-performance liquid chromatography (HPLC). These components isolated from grapefruit juice have 5-geranyloxyfurocoumarin dimer structures showing extremely high affinities for a form of cytochrome P450 (CY...
متن کاملInteraction between Grapefruit Juice and Drugs*
There is a possibility that even a glass of grapefruit juice (GFJ) taken several hours before oral medication may enhance the bioavailability of many drugs, exaggerate the drug action, and increase the toxic effect by exaggerating the potency of the drug. This can be explained by inhibition of CYP3A4 in the small intestine by GFJ, thus suppressing drug metabolism. This interaction with GFJ is l...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1997
ISSN: 0916-1139
DOI: 10.2133/dmpk.12.supplement_122